Hallstensen, Randi; Bergseth, Grete; Foss, Stian; Jæger, Steinar; Gedde-Dahl, Thobias; Holt, jan; Christiansen, Dorte; Lau, Corinna; Brekke, Ole Lars; Armstrong, Elina; Stefanovic, Vedran; Andersen, Jan Terje; Sandlie, Inger; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-13)
Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with
paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this
study was to evaluate whether or not the complement activity in newborns from pregnant women who
receive eculizumab is impaired. A novel eculizumab-C5 complex (E-C5) specific assay was developed
and ...